Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

After the devastating alien attack, disparate pockets of survivors emerge into a shattered world. They quickly realise they must put their differences aside if they are to stand any chance of survival.

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

Lou, feeling like M.O.D.O.K. is stifling his individuality ahead of his bar mitzvah, jumps into M.O.D.O.K.’s portal to Asgard. There, Lou is taken by a tribe of goblins known as Kobolds, but wins them over with his magic tricks and becomes their leader. He refuses to go back home with his dad, so M.O.D.O.K. takes control of an army of Asgardian warriors and wages war against his son. Eventually, M.O.D.O.K. and Lou strike a deal and use Lou's magic tricks to pacify the Kobolds. Meanwhile, the Super Adaptoid agrees to help young M.O.D.O.K.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

After the devastating alien attack, disparate pockets of survivors emerge into a shattered world. They quickly realise they must put their differences aside if they are to stand any chance of survival.

As the dust settles on their brave new world, the survivors are forced to face some cold truths. Catherine is stunned to discover the part she played in bringing about the alien attack. Helen becomes fixated on revenge. And Emily momentarily regains her sight. But is the miracle cause for celebration, or concern?

When patients from the hospital's prescription drug trial start suffering life threatening side effects, Nic fears that her sister Jessie may be in danger. As a result, she and Conrad work to convince Bell that these trials are not worth the risk. Meanwhile, Mina, Austin and Kit must set aside their competitive nature and work together on a patient whose health is quickly deteriorating and Devon uses Julian as the beta tester for a product he's designed.

Conrad goes head-to-head with Bell after he recommends one of Julian's risky medical devices to Zoey, who's already lost one son and is back in the hospital with the other. Nic fears that Conrad may be getting overly attached to his patient. Meanwhile, Mina and Austin grow closer while working on a difficult heart transplant, Devon embarks on a very difficult day and Dr. Lane Hunter returns.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian (guest star Jenna Dewan) makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

Amelia and Simone attempt to perform a high-stakes and groundbreaking brain surgery; Teddy and Bailey attend a medical conference and run into Dr. Cass Beckman; Jo struggles with her irritation toward a younger OB-GYN.

Bailey welcomes a renowned surgeon, whom she greatly admires, to Grey Sloan to help on a challenging case; Teddy, Owen, Jules and Ben team up to save the life of a patient who has been impaled by an ice pick.

A window washer's platform crashes through a hospital window, testing the Grey Sloan team's limits; Blue and Simone clash over their living arrangements; Lucas strives to impress Catherine while on her service.

A new chief starts at Station 19. Meanwhile, the crew responds to a young girl seeking help and a call about an SUV flown over a cliff.

Travis and Theo face danger while responding to an emergency at a haunted house. Ben continues his fight for Baby Pru; Vic opens up to Andy; and Station 19 prepares to welcome patients to the Dean Miller Memorial Clinic.

Lynette tries to put a daycare center in Parcher & Murphy by recruiting employees' children to get the program started. Gabrielle and Sister Mary Bernard face off over Carlos' mission of mercy to Africa. Bree brings Andrew home and tells him about the revelation of George poisoning his father Rex and killing him. Lastly, Susan confronts her biological father's wife after she thinks they are having an affair.

Gabrielle kisses Tom and Lynette is not happy and drives a wedge in her friendship with Gabrielle. Paul attacks Mike. The housewives become more suspicious of Betty and her family. Andrew is trying to blackmail Bree, but Bree gets some assistance from Susan's ex, Karl.

After a number of bad dates, Susan finally meets Dr. Right. Susan flirts with a handsome doctor, but they accidentally head butt. Meanwhile, some old pictures of Gabrielle turn up on the Internet. Tom is alarmed when his kids come down with chicken pox because he never had it. Bree gets arrested. Lastly, after months of silence, Noah Taylor contacts Mike Delfino.

When a popular 17-year-old high school student is found dead after a rave, the team must decipher various unknown drugs in his system and multiple bruises to figure out the cause of death.

The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.

When Max's transmission goes silent, he and Barry seek refuge in an abandoned church while Tristan takes charge of The Odyssey; Avery leads a high-stakes, rescue mission to find Max.

A man, presumed dead, who walks off Ethan's examination table leads the team to a shocking discovery.

Peter stumbles upon a house fire in progress before the fire department arrives and is able to rescue a young woman. When Megan goes to the scene of the fire, she discovers that there is another victim who perished in the fire.

A champion equestrian is killed and potential drug use is suspected, but when Megan's daughter, who also rides, overhears details of the case, she leads the team to a clue and possibly the murderer.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Susan invites Dr. Ron to meet Karl after he finds out about their arranged marriage. Lynette is surprised that a woman at work is still breastfeeding her child of five. Gabrielle becomes very picky when choosing a birth mother, and a beautiful baby. Bree has to deal with a fresh accusation from Andrew, that of repressed memories.

A man, presumed dead, who walks off Ethan's examination table leads the team to a shocking discovery.

Peter stumbles upon a house fire in progress before the fire department arrives and is able to rescue a young woman. When Megan goes to the scene of the fire, she discovers that there is another victim who perished in the fire.

The interns juggle a bizarre trauma; a complex breast reconstruction forces Meredith into a tense partnership.

When patients from the hospital's prescription drug trial start suffering life threatening side effects, Nic fears that her sister Jessie may be in danger. As a result, she and Conrad work to convince Bell that these trials are not worth the risk. Meanwhile, Mina, Austin and Kit must set aside their competitive nature and work together on a patient whose health is quickly deteriorating and Devon uses Julian as the beta tester for a product he's designed.

Conrad goes head-to-head with Bell after he recommends one of Julian's risky medical devices to Zoey, who's already lost one son and is back in the hospital with the other. Nic fears that Conrad may be getting overly attached to his patient. Meanwhile, Mina and Austin grow closer while working on a difficult heart transplant, Devon embarks on a very difficult day and Dr. Lane Hunter returns.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian (guest star Jenna Dewan) makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.