Vic and Theo respond to a domestic disturbance between the parents of a trans teenager; Jack learns shocking new details about his childhood, and Ben and Travis help a clinic patient that's long overdue for medical treatment.

As the dust settles on their brave new world, the survivors are forced to face some cold truths. Catherine is stunned to discover the part she played in bringing about the alien attack. Helen becomes fixated on revenge. And Emily momentarily regains her sight. But is the miracle cause for celebration, or concern?

The survivors make some disarming discoveries not only about the aliens but also about themselves. Mokrani goes on the offensive, taking the fight to the aliens. Ash is forced to make the hardest decision of his life. And Chloe’s past catches up with her, threatening to rip apart the delicate semblance of normality she is so desperately clinging on to.

Trying to emulate human males, Korvo and Terry create their own man cave and “"P.A.T.R.I.C.I.A.", a robot based on female sitcom characters, programmed to hate the man cave. Korvo and Terry realize the robot fulfills their respective desires for a nagging wife and a nurturing mother, and invite her inside the man cave. Torn between her conflicting directives, P.A.T.R.I.C.I.A. transforms into a heavily-armed killing machine and destroys every man cave in the neighborhood. Ms. Perez, Jesse's gender studies teacher, assigns the class to challenge a glass ceiling. Jesse confronts several school extracurriculars, but is disappointed to learn they already welcome women.

Trying to emulate human males, Korvo and Terry create their own man cave and “"P.A.T.R.I.C.I.A.", a robot based on female sitcom characters, programmed to hate the man cave. Korvo and Terry realize the robot fulfills their respective desires for a nagging wife and a nurturing mother, and invite her inside the man cave. Torn between her conflicting directives, P.A.T.R.I.C.I.A. transforms into a heavily-armed killing machine and destroys every man cave in the neighborhood. Ms. Perez, Jesse's gender studies teacher, assigns the class to challenge a glass ceiling. Jesse confronts several school extracurriculars, but is disappointed to learn they already welcome women.

Threatened with expulsion, Yumyulack and Jesse continue to attend their empty high school after the school year ends. Unaware of the summer break, they believe they are being tested, and attempt to teach each other. They realize their mistake and wreak havoc on the school, and are bribed with straight As after discovering Principal Cooke and Mrs. Frankie having sex in the cafeteria. Korvo and Terry enroll in a junior college, but Terry shoots Korvo with a raygun that makes him dumber. Korvo joins Terry's hard-partying college experience, but accidentally causes the "ice lava" that powers their spaceship to flood the city, freezing everyone in its path.

The survivors make some disarming discoveries not only about the aliens but also about themselves. Mokrani goes on the offensive, taking the fight to the aliens. Ash is forced to make the hardest decision of his life. And Chloe’s past catches up with her, threatening to rip apart the delicate semblance of normality she is so desperately clinging on to.

Richard continues to navigate his health; Meredith and Nick are visited by Nick's estranged sister from Boston.

Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition; Bailey joins Owen and Blue on a paramedic ride-along.

The divorce between Gabrielle and Carlos reaches new levels of bitterness. Susan is determined to jog Mike's memory, and realizes Edie has been posing as his girlfriend since he woke up. Tom decides that his dream is to open a pizza parlor, and Lynette is not delighted. Bree tries to break up Danielle and her history teacher, who's been having an affair with her. Meanwhile, Mike's phone number is discovered on a dead woman's body.

Susan professes her love for Ian. Gabrielle and Carlos try to rekindle their love. Bree is confronted with Orson's past. In the meantime, Nora and Lynette go to war.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

Richard continues to navigate his health; Meredith and Nick are visited by Nick's estranged sister from Boston.

Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition; Bailey joins Owen and Blue on a paramedic ride-along.

The divorce between Gabrielle and Carlos reaches new levels of bitterness. Susan is determined to jog Mike's memory, and realizes Edie has been posing as his girlfriend since he woke up. Tom decides that his dream is to open a pizza parlor, and Lynette is not delighted. Bree tries to break up Danielle and her history teacher, who's been having an affair with her. Meanwhile, Mike's phone number is discovered on a dead woman's body.

Susan professes her love for Ian. Gabrielle and Carlos try to rekindle their love. Bree is confronted with Orson's past. In the meantime, Nora and Lynette go to war.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

Bell's confidence in Quovadis continues to waver when the poster child for one of its medical devices, Henry Barnett (guest star Evan Whitten), is rushed back into the ER, experiencing seizure-like symptoms.

Teddy and Winston clash over a case; Owen and Jules treat a urologist; Lucas struggles with prioritizing patients.

Tensions rise as Teddy and Winston take on a complex procedure; Kavita and Ben try to impress the new plastics attending; Jo and Link leave the babies with a nanny for the first time.

Everyone's lives on Wisteria Lane are forever changed when Carolyn Bigsby holds shoppers hostage at a local supermarket. Meanwhile, Gabrielle and Carlos finish dividing their assets: Gabrielle gets the house, and Carlos gets everything in it. Susan is preparing to go to Paris with Ian.

Lynette returns home from the hospital. Gabrielle decides to get back into modeling and travels to New York. Susan comes home to find Austin and Julie making out on her couch. Bree meets her antagonistic mother-in-law Gloria, with whom Orson is in a quarrel. Detective Ridley has Mike's house searched.

Vic and Theo respond to a domestic disturbance between the parents of a trans teenager; Jack learns shocking new details about his childhood, and Ben and Travis help a clinic patient that's long overdue for medical treatment.

An undercover cop is discovered murdered at a truck stop.

A wedding turns into a crime scene after the bride falls to her death and everyone including her father is a suspect. Ethan is captivated by Dani but she's already found another love interest.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

Rosewood and Villa are tasked with solving the murder of a woman whose body was found frozen solid. Outside the precinct, Villa’s brother meets the important people in her life, but isn't yet ready to have a reunion with his mother.

An undercover cop is discovered murdered at a truck stop.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

Vic and Theo respond to a domestic disturbance between the parents of a trans teenager; Jack learns shocking new details about his childhood, and Ben and Travis help a clinic patient that's long overdue for medical treatment.

Everyone's lives on Wisteria Lane are forever changed when Carolyn Bigsby holds shoppers hostage at a local supermarket. Meanwhile, Gabrielle and Carlos finish dividing their assets: Gabrielle gets the house, and Carlos gets everything in it. Susan is preparing to go to Paris with Ian.

The residents of Wisteria Lane celebrate their annual holiday block party. Meanwhile, Gabrielle sets her eyes on a father of a girl she's coaching. Mike is arrested for Monique's murder. Thanks to Lynette, mothers of the neighborhood arrange a protest against Art. This causes his sister a heart attack. And Susan has to cook dinner for Ian's parents.

Richard tackles a shocking case on his first day back; Kavita and Jules prepare for a high-stakes presentation; Bailey must have a difficult conversation with a beloved patient; Jo works to baby-proof the loft.

A couple land in the hospital with life-altering injuries after a wrecking ball destroys their home; Lucas and Simone struggle to support a young, terminally ill patient; Richard hosts a prostate screening event.

The surgeons are determined to shut down Quovadis after Henry Barnett almost loses his life due to a device malfunction. As Mina and Devon set out to find the truth, Bell, AJ and Conrad work to save the life of Chastain's favorite custodian, Simon. Meanwhile, one of Alec's old patients ends up in the ER, forcing him to question if he made the right choice to leave his old practice for Nic's clinic.