When Station 19 receives a call from concerned neighbors regarding a resident in their apartment building, the team heads out to investigate. When they arrive to evaluate the scene, they're shocked by what they find inside. Meanwhile, in an effort to create a solid working relationship between the fire and police departments, Ryan takes an unlikely member of the team on a ride-along.

As people across the globe are experiencing hallucinations, MI5 agent Zoe contacts Bill for answers; Catherine Durand detects unusual black hole activity.

As Adina starts the next stage of her plan, astronauts Juliet and Richard see warning signs in space; uncovering Adina's sinister mission.

M.O.D.O.K brings Melissa and Lou along to a remote GRUMBL leadership conference. After learning that he's not the guest of honor, M.O.D.O.K. enlists Melissa's help in manipulating the executives into respecting him. His schemes accidentally lead to him opening up a portal that brings the dangerously hedonistic alien species, the Ciegrimites, to the conference. While the aliens are initially the life of the party, executives begin to drop dead from partying too hard, leading M.O.D.O.K. and Melissa to wipe out the Ciegrimites and save the conference.

M.O.D.O.K brings Melissa and Lou along to a remote GRUMBL leadership conference. After learning that he's not the guest of honor, M.O.D.O.K. enlists Melissa's help in manipulating the executives into respecting him. His schemes accidentally lead to him opening up a portal that brings the dangerously hedonistic alien species, the Ciegrimites, to the conference. While the aliens are initially the life of the party, executives begin to drop dead from partying too hard, leading M.O.D.O.K. and Melissa to wipe out the Ciegrimites and save the conference.

After getting kicked out of the A-List villains' Soho Lair, M.O.D.O.K. decides to slum it at The Bar With No Name. There, he forms a crew of street-level baddies, intent on using them for a heist that will get him back into the Soho Lair. However, after a wild night of bonding and backstory sharing, they form a real camaraderie. Meanwhile, Jodie goes looking for M.O.D.O.K. at AIM and bonds with Monica while Lou meets Monica's daughter, Carmilla. College-aged M.O.D.O.K. has returned from the time stream and kidnaps the Super Adaptoid.

As Adina starts the next stage of her plan, astronauts Juliet and Richard see warning signs in space; uncovering Adina's sinister mission.

When Maggie takes on a big case, many of the doctors are worried she's not the right one for the job while Stephanie makes a mistake treating one of Grey Sloan's own.

Meredith and Nathan have to confront their feelings when they are stuck sitting next to each other on a plane.

In the aftermath of the tornado, the residents of Wisteria Lane try to rebuild their lives. Katherine discovers someone may know her secret while Lynette faces the possibility of her family's fate.

Two weeks after the tornado, with Mike still in rehab, Mrs. Delfino gets a visit from her cousin Tim. Meanwhile, Bree desperately awaits to return to her own house. Gabrielle learns that Carlos' blindness is permanent. Katherine is unable to keep some of her secrets from the women of Wisteria Lane. Finally, a surprise wedding ceremony has its own share of secrets.

After a plane crashes in Atlanta, Devon is overcome by guilt at the thought that he could have prevented the tragedy. Bell, who was a passenger on the plane, makes it his personal mission to save the life of the man seated next to him. Meanwhile, Adaku returns to ask Mina a big favor, the Raptor struggles with telling his birth parents about meeting his biological father and Conrad and Nic consider risking it all to investigate a drug that might be linked to Jessie’s death.

When Maggie takes on a big case, many of the doctors are worried she's not the right one for the job while Stephanie makes a mistake treating one of Grey Sloan's own.

Meredith and Nathan have to confront their feelings when they are stuck sitting next to each other on a plane.

In the aftermath of the tornado, the residents of Wisteria Lane try to rebuild their lives. Katherine discovers someone may know her secret while Lynette faces the possibility of her family's fate.

Two weeks after the tornado, with Mike still in rehab, Mrs. Delfino gets a visit from her cousin Tim. Meanwhile, Bree desperately awaits to return to her own house. Gabrielle learns that Carlos' blindness is permanent. Katherine is unable to keep some of her secrets from the women of Wisteria Lane. Finally, a surprise wedding ceremony has its own share of secrets.

Emerald embraces her independence, until an unexpected turn forces the team to unite in pursuit of justice.

On National Nurses' Day, Chastain's nurses are severely understaffed and overworked, leaving them all feeling exhausted and underappreciated. Cain performs a dangerous surgery on a new patient he won in a game of poker. Meanwhile, Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death, The Raptor comes face-to-face with his birth mother for the first time and Irving attempts to take the next step in his relationship with Jessica.

Bailey and April work to fix things between Richard and Catherine. Meanwhile, Eliza continues to pursue Arizona, and one of Alex's previous patients returns to Grey Sloan.

April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.

Gabrielle struggles with the reality of having a blind husband. Lynette is surprised when Rick Coletti shows up at the Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball. As part of his recovery, Mike asks a few people for forgiveness, and Orson starts sleepwalking.

Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.

When Station 19 receives a call from concerned neighbors regarding a resident in their apartment building, the team heads out to investigate. When they arrive to evaluate the scene, they're shocked by what they find inside. Meanwhile, in an effort to create a solid working relationship between the fire and police departments, Ryan takes an unlikely member of the team on a ride-along.

Kate meets Sergei, a handsome and mysterious guest at a political event, and is irresistibly drawn to him. But when a young Russian girl is found murdered near the hotel where she and Sergei are having a tryst, Kate suspect and turns to Megan for help.

After Megan questions the grief counselor for one of the victim's parents, she decides to take him up on his offer of counseling her on her own issues about her father's suicide. But Megan is shocked by what she finds in his waiting room.

Emerald embraces her independence, until an unexpected turn forces the team to unite in pursuit of justice.

The Chastain staff works together to diagnose a mother-daughter pair who both come in with symptoms that make it difficult to determine their conditions. Devon deals with an unexpected visit from his mother and Conrad and Nic try to figure out the best time to tell everyone their big news. Meanwhile, Bell deals with an over-eager fan of his show who ends up needing treatment at Chastain and Mina makes a bold move when she realizes her visa is about to expire.

Kate meets Sergei, a handsome and mysterious guest at a political event, and is irresistibly drawn to him. But when a young Russian girl is found murdered near the hotel where she and Sergei are having a tryst, Kate suspect and turns to Megan for help.

Emerald embraces her independence, until an unexpected turn forces the team to unite in pursuit of justice.

When Station 19 receives a call from concerned neighbors regarding a resident in their apartment building, the team heads out to investigate. When they arrive to evaluate the scene, they're shocked by what they find inside. Meanwhile, in an effort to create a solid working relationship between the fire and police departments, Ryan takes an unlikely member of the team on a ride-along.

Gabrielle struggles with the reality of having a blind husband. Lynette is surprised when Rick Coletti shows up at the Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball. As part of his recovery, Mike asks a few people for forgiveness, and Orson starts sleepwalking.

Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.

The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery.

Alex must make a hard decision in his relationship with Jo, while Meredith has some news for Riggs that brings their relationship to a turning point.

When one of Chastain's own is brought into the emergency room with life-threatening injuries, the staff rallies around each other to try to save her life, while disagreements over how to best handle her care put Cain at odds with the rest of the doctors. Also, Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention. Meanwhile, Conrad turns heads when he shares data about Hemopleatin, and Kyle begins volunteering at the hospital.