The stories of people who suffer from rare and mysterious medical conditions. Some need surgery so complex that the odds of survival are slim.

Niki's high school softball career was cut short by her weight. She now wants to coach her son, but her food addiction threatens her plans.

Roger has a considerable growth on his shoulder that he calls his "second head." Jenna is a bubbly teenager with an even bigger bubble behind her ear.

A woman with a life-threatening scar on her foot turns to Dr. Schaeffer for help. And, a man comes in with a terrible case of foot fungus.