Grey Sloan sees the return of a familiar face; Catherine puts on the pressure, forcing Bailey to make a decision about Alex; Amelia faces a tough case at the ER.

When the hospital has a severe blood shortage, Conrad must try every avenue to save a patient's life. Nic receives devastating news and is left worrying about her sister's health, while Mina and Devon work with a new anesthesiologist who is not what she seems. Elsewhere, Kit considers the future of her intertwining relationships and Bell has an encounter with a woman from his past.

Miranda Bailey visits Ben at work, meeting his new co-workers for the first time. While most of the team responds to a motor vehicle accident involving an electrical danger, Andy and Maya are paired up to go on their first stakeout.

Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.

Susan considers moving from Wisteria Lane to London. Later, an accident causes Ian, Susan, and their car to find themselves stranded in a lake. Tom feels threatened by the interest a new Scavo's Pizzeria employee Rick shows in Lynette. While debating his opponent in the mayoral election, Victor Lang witnesses something disturbing.

Devon grows concerned when a mother's complaints go unaddressed after her delivery, and pushes Bell to take drastic measures. Conrad is faced with breaking the news to Nic regarding Jessie's worsening condition. Meanwhile, The Raptor, Mina and Kit spring into action when a mother and son enter the ER with devastating injuries.

A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.

Alex tries to do the right thing but still can't catch a break. Jackson and April adjust to their "new normal" with the baby. While Meredith and Nathan establish what's going on between them, Amelia questions the state of her relationship with Owen.

Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.

Susan considers moving from Wisteria Lane to London. Later, an accident causes Ian, Susan, and their car to find themselves stranded in a lake. Tom feels threatened by the interest a new Scavo's Pizzeria employee Rick shows in Lynette. While debating his opponent in the mayoral election, Victor Lang witnesses something disturbing.

Rosewood and Villa head back to Villa’s roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant.

When the hospital has a severe blood shortage, Conrad must try every avenue to save a patient's life. Nic receives devastating news and is left worrying about her sister's health, while Mina and Devon work with a new anesthesiologist who is not what she seems. Elsewhere, Kit considers the future of her intertwining relationships and Bell has an encounter with a woman from his past.

Meredith and Bailey are at odds when both of their patients need a liver transplant, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for the day, and Amelia struggles with telling Owen some important news.

Grey Sloan sees the return of a familiar face; Catherine puts on the pressure, forcing Bailey to make a decision about Alex; Amelia faces a tough case at the ER.

Gabrielle and Victor will make an unexpected twist in their relationship and will also face a crisis as a video of them sharing a passionate moment in an elevator was caught on tape and is now being used to blackmail them. Edie gets into a fight with one of the ladies that will ruin their "friendship" while another lady on Wisteria Lane ends up in the hospital.

Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.

Miranda Bailey visits Ben at work, meeting his new co-workers for the first time. While most of the team responds to a motor vehicle accident involving an electrical danger, Andy and Maya are paired up to go on their first stakeout.

When a city-wide outbreak of a mysterious and lethal virus occurs, even Megan and her team are at risk. In order to determine who and what caused this outbreak, CDC Officer Charlie Stafford takes over the investigation.

A case of mistaken identity mars a case when two young girls are in a tragic car accident. The wrong girl may have been pronounced dead and the actual cause of death is in question.

Rosewood and Villa head back to Villa’s roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant.

Melinda and Jim's trip is interrupted as Melinda helps the ghost of a woman who left her husband and young daughter. Before the woman can cross over Melinda must find the woman’s daughter and help her to learn the truth about her parent’s past.

When a city-wide outbreak of a mysterious and lethal virus occurs, even Megan and her team are at risk. In order to determine who and what caused this outbreak, CDC Officer Charlie Stafford takes over the investigation.

Rosewood and Villa head back to Villa’s roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant.

Miranda Bailey visits Ben at work, meeting his new co-workers for the first time. While most of the team responds to a motor vehicle accident involving an electrical danger, Andy and Maya are paired up to go on their first stakeout.

A dead body found in the trunk of a car leads the team to another body. Megan meets up with an old friend and Kate feels her job is in jeopardy.

Upon the arrival of Batallion Chief Frankel, Jack begins his first shift as co-captain and continues to butt heads with Andy on leadership styles. Captain Pruitt has a difficult time following doctor’s orders and winds up back at the station to take on administrative duties. Meanwhile, the rest of the team at Station 19 responds to an attic fire at JJ’s apartment building and a call to a pool house party.

As if being co-captains weren’t hard enough, Andy and Jack find themselves in disagreement over spending decisions at the station. Meanwhile, the firefighters respond to a structure fire at a brand-new bed-and-breakfast; and Ryan calls Maya when he finds her brother in some trouble.