In the aftermath of the windstorm, Andy and Sullivan's fates remain unknown while trapped in the overturned aid car. Meanwhile, back at the station, the team confronts Jack about his well-being; and when it's safe enough to venture out, they search for their fellow firefighters in a race against time.

London, four months after the attack. The survivors organize the Resistance. Bill continues his research on aliens and understands that their DNA is human but that their organs are degenerating. In France, a severely wounded dissident alien reaches the Observatory

At the Observatory, Mokrani and Catherine clash over the fate to be reserved for Micah, whom Catherine considers to be a major source of information. Micah reveals to Catherine that she has to find Bill Ward. The latter, for his part, tries to find out more about Emily, still assailed by visions of Adina, the leader of the aliens urging him to kill Bill.

Korvo, increasingly frustrated by Terry, vomits a "red Goobler" – a stress-induced creature intent on killing Korvo. They buy a Jet Ski from Trent, who is killed by the Goobler. Hunting the creature inside a Halloween store, they shrink and capture it. At school, Jesse discovers a flower growing on her head, which releases pollen similar to MDMA, making the popular girls enamored with her. Yumyulack accompanies Jesse to a party and discovers his own flower, with pollen similar to cocaine, and bonds with the popular boys. The mix of Yumyulack and Jesse's pollen creates an effect similar to PCP or bath salts, turning the party-goers bloodthirsty and deranged. Jesse and Yumyulack inform Terry and Korvo, who explain the flowers are a temporary fungus.

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

At the Observatory, Mokrani and Catherine clash over the fate to be reserved for Micah, whom Catherine considers to be a major source of information. Micah reveals to Catherine that she has to find Bill Ward. The latter, for his part, tries to find out more about Emily, still assailed by visions of Adina, the leader of the aliens urging him to kill Bill.

On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.

As the team gathers for a Friendsgiving celebration at Dean's, a violent windstorm touches down in Seattle. As the storm picks up speed, creating dangerous fire conditions, the crew must put the festivities on hold and report for duty, leaving some of them in a life-threatening situation.

There are bullies among the old and young on "Desperate Housewives." Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism; Gaby and Susan find themselves embroiled in a catfight brought on by an altercation between their kids; to her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things; and Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.

Jealousy rears its ugly head on "Desperate Housewives." Bree's new cookbook and entrepreneurial success has the women of Wisteria Lane feeling envious; Lynette's longing for a taste of her breadwinning days as an ad-exec leads her to lend an unsolicited hand to Bree's marketing plan; and MJ's drawing of a family portrait has left Mike feeling like he's not a presence in his son's life. Meanwhile, Gaby hatches a plan to have more sex with Carlos, Susan teaches a reluctant MJ how to fall, and Dave's motives for moving to the neighborhood continue to take shape.

On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.

The doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

It's Thanksgiving and while Meredith faces travel complications, due to the weather, Nick steps in to help – in more ways than one. Richard and Bailey seek out emergency surgeries; Amelia and Link reconnect.

There are bullies among the old and young on "Desperate Housewives." Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism; Gaby and Susan find themselves embroiled in a catfight brought on by an altercation between their kids; to her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things; and Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.

Jealousy rears its ugly head on "Desperate Housewives." Bree's new cookbook and entrepreneurial success has the women of Wisteria Lane feeling envious; Lynette's longing for a taste of her breadwinning days as an ad-exec leads her to lend an unsolicited hand to Bree's marketing plan; and MJ's drawing of a family portrait has left Mike feeling like he's not a presence in his son's life. Meanwhile, Gaby hatches a plan to have more sex with Carlos, Susan teaches a reluctant MJ how to fall, and Dave's motives for moving to the neighborhood continue to take shape.

Carr needs help.

After being terminated from Chastain, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure. In his first move as the new Chief of Surgery, Cain puts the doctors on a commission-based pay system, which causes Devon’s new intern to agree to a procedure before weighing the risks. Meanwhile, Mina struggles with taking care of Adaku’s baby and Bell’s supplement company get its big break.

Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery. Back in Seattle, Link and Jo take their kids to a fairytale theater performance that goes wrong. Bailey and Dr. Lin attend a recruitment fair in hopes of attracting more doctors to Grey Sloan but find themselves ill-prepared.

The doctors celebrate the holidays. Hamilton and Meredith prepare for a milestone on their project, while Link wants to spend the holiday with Amelia and Scout as a family. Schmitt is faced with a difficult decision during surgery.

The night is full of surprises on "Desperate Housewives" as we learn what has transpired on Wisteria Lane in the past five years. Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday; Jackson wants to take his relationship with Susan to the next level; Gaby's concerned she might be pregnant; Tom tells Lynette he's sold the pizzeria; a startling reason for the bond between Bree and Katherine is revealed; and an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

"Hell hath no fury like a woman scorned," on "Desperate Housewives." Gaby is over the moon when Carlos' client makes them an offer they can't refuse, but a startling discovery leaves her second guessing; Lynette grows suspicious that Tom is cheating on her; and after breaking up with Jackson, Susan tries to surprise him, only to find the surprise is on her. Meanwhile, the bond between Bree and Katherine grows, and Mrs. McCluskey enlists the help of her sister to dig up dirt on Dave.

In the aftermath of the windstorm, Andy and Sullivan's fates remain unknown while trapped in the overturned aid car. Meanwhile, back at the station, the team confronts Jack about his well-being; and when it's safe enough to venture out, they search for their fellow firefighters in a race against time.

A schizophrenic girl at a mental institution is murdered. Megan and Tommy interview a young patient who seems sane and lucid, she tells them she saw the killer climb down from a heating vent in the ceiling, but he meant to kill her, not the victim.

A plane crashes in Philadelphia due to a gunman opening fire while aloft. The crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing.

Carr needs help.

With Chastain on the verge of shutting down due to the sale by Red Rock, Conrad tries a last-ditch effort to save the hospital and the doctors plan for their next career moves. Meanwhile, on their last day, the whole staff must work together to save Nic’s life after she is injured by a deranged patient.

A plane crashes in Philadelphia due to a gunman opening fire while aloft. The crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing.

Carr needs help.

In the aftermath of the windstorm, Andy and Sullivan's fates remain unknown while trapped in the overturned aid car. Meanwhile, back at the station, the team confronts Jack about his well-being; and when it's safe enough to venture out, they search for their fellow firefighters in a race against time.

The night is full of surprises on "Desperate Housewives" as we learn what has transpired on Wisteria Lane in the past five years. Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday; Jackson wants to take his relationship with Susan to the next level; Gaby's concerned she might be pregnant; Tom tells Lynette he's sold the pizzeria; a startling reason for the bond between Bree and Katherine is revealed; and an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

"Hell hath no fury like a woman scorned," on "Desperate Housewives." Gaby is over the moon when Carlos' client makes them an offer they can't refuse, but a startling discovery leaves her second guessing; Lynette grows suspicious that Tom is cheating on her; and after breaking up with Jackson, Susan tries to surprise him, only to find the surprise is on her. Meanwhile, the bond between Bree and Katherine grows, and Mrs. McCluskey enlists the help of her sister to dig up dirt on Dave.

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own. Meredith works to save Dr. Hamilton's life; Levi is impacted from his latest loss.

Schmitt must face the Morbidity and Mortality Conference. Meredith convinces Nick to scrub in on a surgery in Seattle. Jo faces her feelings.

While working at their non-profit clinic three hours outside of Atlanta, Nic and Mina treat a patient with a failing heart VAD, forcing them to find a new battery in time to save her life. Conrad gets a call from a previous patent in crisis after being sued by Red Rock for medical expenses he can't afford. Meanwhile, Devon's VIP patient, Nadine, returns to the ER and Cain tries to get close to Bell's business partner from the supplement company.