Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

As the dust settles on their brave new world, the survivors are forced to face some cold truths. Catherine is stunned to discover the part she played in bringing about the alien attack. Helen becomes fixated on revenge. And Emily momentarily regains her sight. But is the miracle cause for celebration, or concern?

The survivors make some disarming discoveries not only about the aliens but also about themselves. Mokrani goes on the offensive, taking the fight to the aliens. Ash is forced to make the hardest decision of his life. And Chloe’s past catches up with her, threatening to rip apart the delicate semblance of normality she is so desperately clinging on to.

Jodie's celebrity is on the rise and M.O.D.O.K. plans on winning her back from her new boyfriend, the superhero Wonder Man. Jodie and her publicist invite M.O.D.O.K. to a party, knowing his temper will bring publicity. M.O.D.O.K. provokes Wonder Man into attacking him at the party and is kicked out. Wonder Man leaves Jodie when he sees she’s only using him for exposure. Melissa and Lou bond over their disappointment in their parents. M.O.D.O.K. and Jodie have sex when he goes to apologize, and it is revealed who exactly was behind her publicist’s actions.

Young M.O.D.O.K. has kidnapped the family and replaced them with robots that trick M.O.D.O.K. into thinking Jodie wants him back. M.O.D.O.K. learns the truth and goes to free his real family. The family meet up inside the carnival-themed arena Murderworld, where young M.O.D.O.K. and Arcade reveal that each family member has two robotic replicas and that they must fight to the death, unsure of who is real or fake. Jodie goes toe-to-toe with Young M.O.D.O.K. The family leaves feeling united for the first time in a while.

The survivors make some disarming discoveries not only about the aliens but also about themselves. Mokrani goes on the offensive, taking the fight to the aliens. Ash is forced to make the hardest decision of his life. And Chloe’s past catches up with her, threatening to rip apart the delicate semblance of normality she is so desperately clinging on to.

Cracks start to show as the survivors find different ways to cope. Jonathan’s increasingly perturbed by Sacha’s strange behaviour. Emily proves to be an exciting conundrum for Bill. And Mokrani is horrified as his men delight in the opportunity to exact revenge.

The alien’s connection to certain survivors raises difficult questions. Bill makes a startling discovery. Sacha’s behaviour is increasingly erratic. And Tom’s birthday proves cause for celebration. But at what cost?

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

When a medical device fails on a former Chastain employee, an investigation is opened up, which pits Dr. AJ Austin against Quovadis. As Mina and Bell work to get to the bottom of what went wrong, Devon distracts himself with another patient who's experiencing mysterious stomach pains. Meanwhile, Nic forms a bond with her new partner at the clinic and Conrad's relationship with the Barnett family continues to grow.

Amelia undertakes a high-risk brain surgery on a young patient; Winston and Jules disagree over how to handle their trauma patient's family; Jo and Link struggle with wedding planning.

Jo and Link's wedding day arrives, along with some visitors; Teddy and Owen are met with a familiar face seeking treatment; Lucas disagrees with Simone on how to approach a patient's worsened condition.

The interns are excited to transition to second-year residency; a medical emergency unfolds in the operating room, endangering lives inside the hospital.

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own; confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

The Station 19 crew offers aid to a man who sets himself on fire. Theo proves his devotion to Vic; Sullivan seeks advice from Dr. Webber; and Travis comes to a realization about his love life.

The Dean Miller Memorial Clinic has its opening day. Meanwhile, Sullivan gives Beckett an ultimatum, and the crew responds to a skydiving incident.

Sullivan and Natasha's past is revealed. Ben and Bailey have a discussion with Pru's grandparents. The crew responds to a fire at a candy factory.

Dr. Ron informs Susan that she needs a splenectomy. Gabrielle and her arch-enemy Sister Mary Bernard finally face off in church. Also, Tom decides to apply for an empty position at Lynette's job, which leads to the arousal of past issues in their marriage. Lastly, Matthew and Danielle's relationship is found out by both their mothers, which leads to big repercussions later on for Bree and her past secret with Andrew last year.

Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.

When a pharmaceutical rep is murdered, Megan and the team must find the original crime scene if they hope to find out the cause of death and why the body was drained of blood. A big hurdle to overcome is the number of suspects with access to lots of unknown drugs.

A new chief starts at Station 19. Meanwhile, the crew responds to a young girl seeking help and a call about an SUV flown over a cliff.

Travis and Theo face danger while responding to an emergency at a haunted house. Ben continues his fight for Baby Pru; Vic opens up to Andy; and Station 19 prepares to welcome patients to the Dean Miller Memorial Clinic.

A champion equestrian is killed and potential drug use is suspected, but when Megan's daughter, who also rides, overhears details of the case, she leads the team to a clue and possibly the murderer.

When a popular 17-year-old high school student is found dead after a rave, the team must decipher various unknown drugs in his system and multiple bruises to figure out the cause of death.

When a pharmaceutical rep is murdered, Megan and the team must find the original crime scene if they hope to find out the cause of death and why the body was drained of blood. A big hurdle to overcome is the number of suspects with access to lots of unknown drugs.

An anonymous tip to the LAPD sparks an unusual multiple-victim kidnapping investigation, forcing the team to rely on board games and puzzles to track down their suspect.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America’s space program. Rosie navigates new dynamics regarding his latest health issue, and Villa’s long-lost brother returns to Miami.

After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients.

The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations; Meredith spends time with Amelia.

A high-risk lung transplant pushes the surgical team to their limits; Bailey juggles a trauma patient whose treatment hangs in the balance.

It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.

Jo navigates a challenging case with a pregnant mother; Blue and Jules care for a diabetic patient; Simone treats a patient with a surprising revelation.

Grey Sloan takes in patients following a catastrophic bus accident; Teddy and Owen have an awkward encounter; Richard tests Bailey's patience.

When a nasty flu season turns out to be masking a terribly infectious disease, Chastain must race to quarantine and diagnose infected patients. While Conrad, Nic and Alec work tirelessly on Meg, who was Nic's favorite guard from her stint in prison, Devon and the others treat Sam, a love-sick patient with flu-like symptoms. Mina finds herself testing Quovadis medical devices in an effort to defend Dr. AJ Austin, who, feeling responsible for the death of a patient, is serving penance by staying away from the OR. Meanwhile, Conrad is prepared to take the next step with Nic, but finds that she may not be as ready.