It is raining on Wisteria Lane, six months after Mike was run over. He is now in a coma, with Susan by his side. Bree gets engaged to Orson. Gabrielle and Carlos are getting divorced, but they are briefly reunited when their 8½ months pregnant surrogate Xiao-Mei runs away. While adjusting to having another child around the house, Lynette realizes that the girl's mother, Nora, is more than she can handle.

It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.

When a nasty flu season turns out to be masking a terribly infectious disease, Chastain must race to quarantine and diagnose infected patients. While Conrad, Nic and Alec work tirelessly on Meg, who was Nic's favorite guard from her stint in prison, Devon and the others treat Sam, a love-sick patient with flu-like symptoms. Mina finds herself testing Quovadis medical devices in an effort to defend Dr. AJ Austin, who, feeling responsible for the death of a patient, is serving penance by staying away from the OR. Meanwhile, Conrad is prepared to take the next step with Nic, but finds that she may not be as ready.

Jo navigates a challenging case with a pregnant mother; Blue and Jules care for a diabetic patient; Simone treats a patient with a surprising revelation.

Grey Sloan takes in patients following a catastrophic bus accident; Teddy and Owen have an awkward encounter; Richard tests Bailey's patience.

It is raining on Wisteria Lane, six months after Mike was run over. He is now in a coma, with Susan by his side. Bree gets engaged to Orson. Gabrielle and Carlos are getting divorced, but they are briefly reunited when their 8½ months pregnant surrogate Xiao-Mei runs away. While adjusting to having another child around the house, Lynette realizes that the girl's mother, Nora, is more than she can handle.

It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.

Oz faces a deeply personal struggle when he discovers his late father's headstone was never ordered; the team investigates the murder of a tech founder obsessed with life extension.

Conrad, Kit, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

Winston and Ben fight to save Jo's life; Teddy supports Link; Owen and Jules battle to save a young man; Lucas forms an unexpected bond with a patient.

Bailey and Owen join forces to save a tumor patient; Richard faces an internal battle; Jules struggles with her feelings for Winston.

It is a holiday weekend on Wisteria Lane. Bree and Orson are going on their honeymoon, while Gabrielle and Lynette are going a spa vacation and Tom is going on a camping trip with the kids. Meanwhile Susan is going on a quiet romantic getaway with Ian, not sure if she's cheating on Mike. However, things don't go as planned.

Mike has woken up from his coma, and has no recollection of the past two years, and Edie is there to fill in the blanks. Susan is still in the country with Ian, when she receives the news. Bree finds her family is anything but perfect. Lynette is determined not to let Parker quit baseball because he made a commitment, even though he's terrible at it. Carlos moves back into the Solis house, much to Gabrielle's displeasure.

Andy deals with the aftermath of a trauma.

Everyone becomes a suspect when a lottery winner is viciously murdered.

A murdered young woman's body turns up in place of a medical school cadaver during class, leaving Megan to rely on the aid of the star student to help solve the case.

Oz faces a deeply personal struggle when he discovers his late father's headstone was never ordered; the team investigates the murder of a tech founder obsessed with life extension.

The firm's tenth anniversary brings two high-profile cases. Allura's personal life takes a dramatic turn.

Everyone becomes a suspect when a lottery winner is viciously murdered.

Oz faces a deeply personal struggle when he discovers his late father's headstone was never ordered; the team investigates the murder of a tech founder obsessed with life extension.

Andy deals with the aftermath of a trauma.

It is a holiday weekend on Wisteria Lane. Bree and Orson are going on their honeymoon, while Gabrielle and Lynette are going a spa vacation and Tom is going on a camping trip with the kids. Meanwhile Susan is going on a quiet romantic getaway with Ian, not sure if she's cheating on Mike. However, things don't go as planned.

Susan professes her love for Ian. Gabrielle and Carlos try to rekindle their love. Bree is confronted with Orson's past. In the meantime, Nora and Lynette go to war.

Richard continues to navigate his health; Meredith and Nick are visited by Nick's estranged sister from Boston.

Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition; Bailey joins Owen and Blue on a paramedic ride-along.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.