While Pruitt grieves a monumental loss, Andy refuses to do the same and, instead, throws herself into work. Meanwhile, the crew responds to a widespread carbon monoxide leak, and Sullivan makes a controversial choice for captain.

Catherine, Sophia, Zoe and the other survivors, finally reunited, prepare for the ultimate attack. But it is Bill who is the only one to hold the destiny of humanity in his hands, provided he is helped by Isla.

As people across the globe are experiencing hallucinations, MI5 agent Zoe contacts Bill for answers; Catherine Durand detects unusual black hole activity.

Korvo, increasingly frustrated by Terry, vomits a "red Goobler" – a stress-induced creature intent on killing Korvo. They buy a Jet Ski from Trent, who is killed by the Goobler. Hunting the creature inside a Halloween store, they shrink and capture it. At school, Jesse discovers a flower growing on her head, which releases pollen similar to MDMA, making the popular girls enamored with her. Yumyulack accompanies Jesse to a party and discovers his own flower, with pollen similar to cocaine, and bonds with the popular boys. The mix of Yumyulack and Jesse's pollen creates an effect similar to PCP or bath salts, turning the party-goers bloodthirsty and deranged. Jesse and Yumyulack inform Terry and Korvo, who explain the flowers are a temporary fungus.

Super villain M.O.D.O.K. runs his evil organization AIM into the ground and is forced to sell it to the tech company GRUMBL. As the megalomaniacal M.O.D.O.K. struggles to regain control of AIM, he risks losing something even more important…his family!

In a bid to save his marriage, M.O.D.O.K. takes Jodie back in time to a concert they missed when they were in college. During a detour to kill the child-version of his GRUMBL boss, M.O.D.O.K. and Jodie are attacked by college-aged M.O.D.O.K., who accidentally absorbs their time crystals, stranding them in 2002. The couple reconciles but is stuck in the past until they catch up to the present. Once in the present, they prevent themselves from ever going to the past in the first place, erasing their entire adventure from the timeline.

At the Observatory, Mokrani and Catherine clash over the fate to be reserved for Micah, whom Catherine considers to be a major source of information. Micah reveals to Catherine that she has to find Bill Ward. The latter, for his part, tries to find out more about Emily, still assailed by visions of Adina, the leader of the aliens urging him to kill Bill.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong (guest star Conrad Ricamora). Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

The new Seattle fire chief is introduced to STATION 19 and leaves the crew skeptical after his visit. Later, the firefighters are called to a department store fire caused by exploding fireworks, which triggers painful memories from Ben's past and inspires him to pursue a new endeavor. Maya advocates for herself and her career, while Jack becomes more intertwined with an acquaintance; and Andy and Ryan have a heart-to-heart.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong (guest star Conrad Ricamora). Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

Simone is met with a life-changing decision upon the return of someone from her past; Blue and Jules shadow Maggie on a risky case; Jo and Link tend to a pregnant woman; Lucas and Mika throw a party filled with surprises.

Catherine returns to Grey Sloan for a surgical case that makes Lucas and Blue queasy; Amelia treats a possible cancer patient with a family that's a little too supportive; Owen takes his medical future into his own hands, much to Teddy's surprise.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

After a family tragedy, John seeks comfort from Carolyn.

When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain’s doctors to put aside their personal issues to try and save his life. Conrad and Nic team up to help one of the crash victims, whose secretive past makes it difficult to identify a diagnosis. Meanwhile, Bell brings his TV crew to the hospital in hopes of garnering positive attention for Chastain, and Mina opens up to Nic, only to find out that Nic is holding on to a secret of her own.

Addison makes a special appearance at Grey Sloan to welcome Bailey's new OB/GYN trainees; Maggie's lung transplant is derailed; Nick bonds with Lucas before the day takes a shocking turn.

In the immediate aftermath of shocking events at the clinic, the hospital goes on lockdown and the Grey Sloan doctors split up to save multiple lives; Maggie lands in hot water with Winston; Jules' roommate makes a surprise appearance.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

While Pruitt grieves a monumental loss, Andy refuses to do the same and, instead, throws herself into work. Meanwhile, the crew responds to a widespread carbon monoxide leak, and Sullivan makes a controversial choice for captain.

Amidst the glitz and glamour of Miami Fashion Week, there’s a plot to kill one of the city’s hottest new designers, who turns to Rosewood for help. As the case takes Rosewood and Villa from the catwalk to the perp walk, Rosewood learns of his shared past with the victim. When he enlists the aid of his best friend, Dr. Mike Boyce, Rosewood unintentionally gives Villa the jolt she needs to get back into the dating pool. Potential love also is in the air for Donna, who tries her hand at online dating. Meanwhile, Pippy and TMI find their romance on the skids when Pippy discovers TMI has kept an important secret from her.

Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." When TMI’s ex-fiancé, FBI Detective Heath Casablanca, joins the hunting party, he threatens to sabotage Pippy and TMI’s relationship. Heath also butts heads with Hornstock, who stands to take over as police chief if he can catch the killer. Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab and forces Donna to take a long hard look at the way her son lives his life. Also, Rosewood tries to protect Villa from his best friend, Mike.

After a family tragedy, John seeks comfort from Carolyn.

Melinda has trouble talking to a ghost only to find that it's because he is not dead but is in a coma. While Lisa, his wife is in a legal battle against his parents to take him off of the life support.

Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." When TMI’s ex-fiancé, FBI Detective Heath Casablanca, joins the hunting party, he threatens to sabotage Pippy and TMI’s relationship. Heath also butts heads with Hornstock, who stands to take over as police chief if he can catch the killer. Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab and forces Donna to take a long hard look at the way her son lives his life. Also, Rosewood tries to protect Villa from his best friend, Mike.

After a family tragedy, John seeks comfort from Carolyn.

While Pruitt grieves a monumental loss, Andy refuses to do the same and, instead, throws herself into work. Meanwhile, the crew responds to a widespread carbon monoxide leak, and Sullivan makes a controversial choice for captain.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

All good things eventually come to an end, and in the final season of this landmark show, the stakes are at an all-time high. Winner of both the 2005 and 2006 Golden Globe Award for Best Television Series -- Musical or Comedy – “Desperate Housewives” is a primetime soap with a truly contemporary take on “happily ever after.” The series, which takes a darkly comedic look at suburbia -- where the secret lives of housewives aren’t always what they seem -- began with Mary Alice Young inside her perfect house, in the loveliest of suburbs, taking her own life. Commenting from her elevated point of view, she took us into the lives of her family, friends and neighbors.

While testifying for the prosecution during a murder trial, Rosewood engages in a pathology chess match with the expert witness for the defense – his father. Then, when Donna and Beaumont Sr. make an unexpected announcement, it has unforeseen consequences.

Bailey recruits the interns to create a series of social media videos informing teens about sexual health. The videos, filmed at Grey Sloan in front of a group of high schoolers, hit home as a student has medical complications during her visit. Elsewhere, Meredith and Maggie learn something new about Zola.

It’s Halloween night at Grey Sloan Memorial. Meredith and Nick try to spend some alone time together; Levi is stressed due to overworking, and Winston and Owen have the interns practice trauma training on a real cadaver.