The attending surgeons and interns work together to solve a medical mystery when a college kid comes in with what first looks like food poisoning but has escalating and dire complications; Jo spends her day off with Bailey.

The alien’s connection to certain survivors raises difficult questions. Bill makes a startling discovery. Sacha’s behaviour is increasingly erratic. And Tom’s birthday proves cause for celebration. But at what cost?

Tragedy strikes, altering the course of the future forever. Catherine’s priorities change with the arrival of Sophia. Things come to a head between Jonathan and Sacha. And Emily’s so happy she can see again that she’s stopped asking why, even if others haven’t...

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

Far out! Korvo and Terry manipulate each other with time travel while Yumyulack grows a fat hog.

As the dust settles on their brave new world, the survivors are forced to face some cold truths. Catherine is stunned to discover the part she played in bringing about the alien attack. Helen becomes fixated on revenge. And Emily momentarily regains her sight. But is the miracle cause for celebration, or concern?

The survivors make some disarming discoveries not only about the aliens but also about themselves. Mokrani goes on the offensive, taking the fight to the aliens. Ash is forced to make the hardest decision of his life. And Chloe’s past catches up with her, threatening to rip apart the delicate semblance of normality she is so desperately clinging on to.

Cracks start to show as the survivors find different ways to cope. Jonathan’s increasingly perturbed by Sacha’s strange behaviour. Emily proves to be an exciting conundrum for Bill. And Mokrani is horrified as his men delight in the opportunity to exact revenge.

A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.

Conrad finds himself caught between his duties as a doctor and his loyalty to Kit, when he discovers that her son-in-law may be suffering from a serious disease. While moonlighting at a long-term care facility, Devon and Nic make a shocking discovery about a former patient who fell victim to Cain's manipulative practices. Meanwhile, after jumping into a new opportunity as a TV doctor, Bell is left without any surgeries and The Raptor brings him in to help on an important case.

A former patient of Link's, named Simon, is in the emergency room with his pregnant wife. Bailey receives an offer from Nick.

A dinner party is thrown at the sister house in Nick's honor; Grey Sloan Memorial receives a victim of a brutal hate crime.

Due to a blood shortage, Grey Sloan Memorial sets up a voluntary donation center. Nick asks Meredith for help with his patient. Winston is hung up on his relationship with his brother.

The blood shortage continues. Meredith makes a risky decision regarding a patient. Owen's actions to help his fellow veterans come to light.

A blackout in Seattle creates dangerous situations throughout the city and the members of Station 19 head out on calls, including locating a missing girl and helping a man on life support where every second counts.

When Station 19 gets called to a structure fire at a coffee processing plant, the team risks their lives to save Station 42’s captain.

Friendliness is disguised as a hidden agenda. When Susan tries to impress Jessie (Swoosie Kurtz), a teacher at work, Jessie comes away with the wrong impression; with the wrong intent, Gaby convinces Carlos to hire Lynette; as Orson's shameful habit grows, Bree will protect herself from embarrassment at all costs; and a suspicious Edie slyly digs further into Dave's past.

Life is full of nasty shocks. Bree considers selling her business to save her marriage, Lynette is threatened by her new boss, boundaries are crossed for Gaby and Carlos, Katherine is caught in the most unexpected of circumstances and Edie's worst fears come true.

Meredith, still functioning as the interim chief, sees Nick for the first time since she rejected his offer to move to Minnesota; Bailey tells Richard she is not ready to return to work; Levi works up the courage to break disappointing news to Jo.

The attending surgeons and interns work together to solve a medical mystery when a college kid comes in with what first looks like food poisoning but has escalating and dire complications; Jo spends her day off with Bailey.

John juggles his mother’s waning health, his strained relationship with Daryl and his newfound feelings for Carolyn.

Nicollette Sheridan takes her final stroll down Wisteria Lane in unforgettable fashion. As the women look back on Edie’s life, Susan recalls their first meeting, Lynette reflects on a memorable night out, Bree is reminded of the thoughtfulness she bestowed upon Orson, and Gaby remembers fondly a night of friendly competition.

Covering up the truth leads to unexpected consequences. Carlos finds Lynette in a precarious position, which she chooses to hide from Tom; Gaby hastily covers for Tom’s coy behavior; Orson tries to hide the truth about his wounds from Bree; Katherine confesses to Mike, which leads to a surprising realization; and Susan confides her dark secret in Dave.

When Rosewood and Villa suspect a brilliant doctor has killed two of his patients, they must find a way to make their case with limited evidence. Meanwhile, Villa spars with Captain Hornstock when he discourages her from pursuing an uncertain case. Also, Rosewood receives an anonymous letter revealing something that could change his life forever.

Rosewood and Villa make it their mission to seek justice for a murder victim who is an ex-con with ties to a Little Haiti gang. Meanwhile, Villa struggles with dreams she’s been having, and Rosewood deals with an unexpected turn in his relationship with Kat.

It’s almost Halloween, and the team investigates a spooky case where a wealthy lawyer is found dead in his haunted Victorian mansion, while Captain Wagner surprises everyone with his skills. At home, Eliott plays mediator between Morgan and Ava.

A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.

When Rosewood and Villa suspect a brilliant doctor has killed two of his patients, they must find a way to make their case with limited evidence. Meanwhile, Villa spars with Captain Hornstock when he discourages her from pursuing an uncertain case. Also, Rosewood receives an anonymous letter revealing something that could change his life forever.

Following a deadly blaze inside a coffee beanery, the members of Station 19 find themselves on high alert as one of their team lands at Grey Sloan, leaving the future uncertain in the face of a life-threatening situation.

Catherine faces audits for several of her foundation hospitals. Addison returns to Grey Sloan. Tensions rise between Meredith and Richard; Owen goes back to work.

A dinner party is thrown at the sister house in Nick's honor; Grey Sloan Memorial receives a victim of a brutal hate crime.

Bailey recruits the interns to create a series of social media videos informing teens about sexual health. The videos, filmed at Grey Sloan in front of a group of high schoolers, hit home as a student has medical complications during her visit. Elsewhere, Meredith and Maggie learn something new about Zola.

It’s Halloween night at Grey Sloan Memorial. Meredith and Nick try to spend some alone time together; Levi is stressed due to overworking, and Winston and Owen have the interns practice trauma training on a real cadaver.

When Cain becomes aware of an emergency situation breaking out at the hospital, he recruits Ezra to help keep it under wraps. Also, Nic works to come up with a support system for a patient in need of a lung transplant. Meanwhile, Kitt's son-in-law's condition continues to worsen.