When Station 19 gets called to a structure fire at a coffee processing plant, the team risks their lives to save Station 42’s captain.

With Adina's plan in motion, the world's last hope is for Bill to make one more journey, risking his own life in search of Catherine's help.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

Jodie's celebrity is on the rise and M.O.D.O.K. plans on winning her back from her new boyfriend, the superhero Wonder Man. Jodie and her publicist invite M.O.D.O.K. to a party, knowing his temper will bring publicity. M.O.D.O.K. provokes Wonder Man into attacking him at the party and is kicked out. Wonder Man leaves Jodie when he sees she’s only using him for exposure. Melissa and Lou bond over their disappointment in their parents. M.O.D.O.K. and Jodie have sex when he goes to apologize, and it is revealed who exactly was behind her publicist’s actions.

Korvo, increasingly frustrated by Terry, vomits a "red Goobler" – a stress-induced creature intent on killing Korvo. They buy a Jet Ski from Trent, who is killed by the Goobler. Hunting the creature inside a Halloween store, they shrink and capture it. At school, Jesse discovers a flower growing on her head, which releases pollen similar to MDMA, making the popular girls enamored with her. Yumyulack accompanies Jesse to a party and discovers his own flower, with pollen similar to cocaine, and bonds with the popular boys. The mix of Yumyulack and Jesse's pollen creates an effect similar to PCP or bath salts, turning the party-goers bloodthirsty and deranged. Jesse and Yumyulack inform Terry and Korvo, who explain the flowers are a temporary fungus.

Trying to emulate human males, Korvo and Terry create their own man cave and “"P.A.T.R.I.C.I.A.", a robot based on female sitcom characters, programmed to hate the man cave. Korvo and Terry realize the robot fulfills their respective desires for a nagging wife and a nurturing mother, and invite her inside the man cave. Torn between her conflicting directives, P.A.T.R.I.C.I.A. transforms into a heavily-armed killing machine and destroys every man cave in the neighborhood. Ms. Perez, Jesse's gender studies teacher, assigns the class to challenge a glass ceiling. Jesse confronts several school extracurriculars, but is disappointed to learn they already welcome women.

Bill's latest discovery is put in jeopardy, even as trouble brews with the human aliens; Catherine must decide where her loyalties lie.

When Nadine's father comes to town for her birthday, Devon enlists the help of the whole staff, as well as one of his patients, to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department and Logan Kim leaves Conrad with the difficult task of letting the residents go. Meanwhile, Nic cares for a teenage patient whose condition is deteriorating.

A blackout in Seattle creates dangerous situations throughout the city and the members of Station 19 head out on calls, including locating a missing girl and helping a man on life support where every second counts.

The residents of Wisteria Lane work hard to provide for the ones they love. Susan starts a new job in order to give son MJ the best, but when Mike leaves their son in Katherine's care, anger and jealousy pervade; as Scavo's Pizzeria continues to take a hit in the current economy, Lynette tells Tom they have to sell; Carlos receives a generous bonus when Gaby discovers his boss' dirty little secret; and Orson confronts Bree when he learns she's given Andrew a raise. Meanwhile, Dave grows weary the neighbors are beginning to suspect he's up to no good.

When tact and kindness are not reciprocated, turnabout is fair play. In a gesture of friendship, Bree tells Lynette she'll help Tom secure a new job, but the best intentions will reach a tempestuous end and reveal Orson's shameful misdeeds; Gaby finds herself in a precarious position when Carlos' adulterous boss begins using her to cover for himself as he continues to cheat on his wife; and Edie digs into Dave's past after a chance encounter with an old acquaintance.

When Nadine's father comes to town for her birthday, Devon enlists the help of the whole staff, as well as one of his patients, to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department and Logan Kim leaves Conrad with the difficult task of letting the residents go. Meanwhile, Nic cares for a teenage patient whose condition is deteriorating.

A former patient of Link's, named Simon, is in the emergency room with his pregnant wife. Bailey receives an offer from Nick.

A dinner party is thrown at the sister house in Nick's honor; Grey Sloan Memorial receives a victim of a brutal hate crime.

The residents of Wisteria Lane work hard to provide for the ones they love. Susan starts a new job in order to give son MJ the best, but when Mike leaves their son in Katherine's care, anger and jealousy pervade; as Scavo's Pizzeria continues to take a hit in the current economy, Lynette tells Tom they have to sell; Carlos receives a generous bonus when Gaby discovers his boss' dirty little secret; and Orson confronts Bree when he learns she's given Andrew a raise. Meanwhile, Dave grows weary the neighbors are beginning to suspect he's up to no good.

When tact and kindness are not reciprocated, turnabout is fair play. In a gesture of friendship, Bree tells Lynette she'll help Tom secure a new job, but the best intentions will reach a tempestuous end and reveal Orson's shameful misdeeds; Gaby finds herself in a precarious position when Carlos' adulterous boss begins using her to cover for himself as he continues to cheat on his wife; and Edie digs into Dave's past after a chance encounter with an old acquaintance.

As Nic struggles with her recovery, her close friend and former Chastain colleague, Billie, comes back to the hospital to support her. Meanwhile, as the hospital transitions from private to public, the search begins for a new CEO, Bell asks a favor of his step-son (guest star Conrad Ricamora) and Devon sees an opportunity to fix the system.

A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.

Due to a blood shortage, Grey Sloan Memorial sets up a voluntary donation center. Nick asks Meredith for help with his patient. Winston is hung up on his relationship with his brother.

The blood shortage continues. Meredith makes a risky decision regarding a patient. Owen's actions to help his fellow veterans come to light.

Friendliness is disguised as a hidden agenda. When Susan tries to impress Jessie (Swoosie Kurtz), a teacher at work, Jessie comes away with the wrong impression; with the wrong intent, Gaby convinces Carlos to hire Lynette; as Orson's shameful habit grows, Bree will protect herself from embarrassment at all costs; and a suspicious Edie slyly digs further into Dave's past.

Life is full of nasty shocks. Bree considers selling her business to save her marriage, Lynette is threatened by her new boss, boundaries are crossed for Gaby and Carlos, Katherine is caught in the most unexpected of circumstances and Edie's worst fears come true.

When Station 19 gets called to a structure fire at a coffee processing plant, the team risks their lives to save Station 42’s captain.

A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.

When Rosewood and Villa suspect a brilliant doctor has killed two of his patients, they must find a way to make their case with limited evidence. Meanwhile, Villa spars with Captain Hornstock when he discourages her from pursuing an uncertain case. Also, Rosewood receives an anonymous letter revealing something that could change his life forever.

As Nic struggles with her recovery, her close friend and former Chastain colleague, Billie, comes back to the hospital to support her. Meanwhile, as the hospital transitions from private to public, the search begins for a new CEO, Bell asks a favor of his step-son (guest star Conrad Ricamora) and Devon sees an opportunity to fix the system.

John juggles his mother’s waning health, his strained relationship with Daryl and his newfound feelings for Carolyn.

When Rosewood and Villa suspect a brilliant doctor has killed two of his patients, they must find a way to make their case with limited evidence. Meanwhile, Villa spars with Captain Hornstock when he discourages her from pursuing an uncertain case. Also, Rosewood receives an anonymous letter revealing something that could change his life forever.

As Nic struggles with her recovery, her close friend and former Chastain colleague, Billie, comes back to the hospital to support her. Meanwhile, as the hospital transitions from private to public, the search begins for a new CEO, Bell asks a favor of his step-son (guest star Conrad Ricamora) and Devon sees an opportunity to fix the system.

When Station 19 gets called to a structure fire at a coffee processing plant, the team risks their lives to save Station 42’s captain.

Friendliness is disguised as a hidden agenda. When Susan tries to impress Jessie (Swoosie Kurtz), a teacher at work, Jessie comes away with the wrong impression; with the wrong intent, Gaby convinces Carlos to hire Lynette; as Orson's shameful habit grows, Bree will protect herself from embarrassment at all costs; and a suspicious Edie slyly digs further into Dave's past.

Life is full of nasty shocks. Bree considers selling her business to save her marriage, Lynette is threatened by her new boss, boundaries are crossed for Gaby and Carlos, Katherine is caught in the most unexpected of circumstances and Edie's worst fears come true.

Meredith, still functioning as the interim chief, sees Nick for the first time since she rejected his offer to move to Minnesota; Bailey tells Richard she is not ready to return to work; Levi works up the courage to break disappointing news to Jo.

The attending surgeons and interns work together to solve a medical mystery when a college kid comes in with what first looks like food poisoning but has escalating and dire complications; Jo spends her day off with Bailey.

Conrad finds himself caught between his duties as a doctor and his loyalty to Kit, when he discovers that her son-in-law may be suffering from a serious disease. While moonlighting at a long-term care facility, Devon and Nic make a shocking discovery about a former patient who fell victim to Cain's manipulative practices. Meanwhile, after jumping into a new opportunity as a TV doctor, Bell is left without any surgeries and The Raptor brings him in to help on an important case.