Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

Catherine, Sophia, Zoe and the other survivors, finally reunited, prepare for the ultimate attack. But it is Bill who is the only one to hold the destiny of humanity in his hands, provided he is helped by Isla.

As people across the globe are experiencing hallucinations, MI5 agent Zoe contacts Bill for answers; Catherine Durand detects unusual black hole activity.

When the Pupa turns orange, Korvo realizes he left important Pupa information in his wallet on Shlorp. He and Terry travel back in time to the day they evacuated Shlorp, and knock Korvo's wallet into their spaceship. Returning to the present, they realize the Pupa merely ate something orange, but the time stream has been altered and they now live with Vanbo, an obnoxious Shlorpian. Returning to the past to set things right, Korvo and Terry learn they did not want each other as evacuation partners, but reconcile and beat up Vanbo. Yumyulack discovers Jesse has simulated a nicer version of himself in the "Pretend-O-Deck". His simulated self teaches him to be a better brother to Jesse, but one Yumyulack kills the other.

Young M.O.D.O.K. has kidnapped the family and replaced them with robots that trick M.O.D.O.K. into thinking Jodie wants him back. M.O.D.O.K. learns the truth and goes to free his real family. The family meet up inside the carnival-themed arena Murderworld, where young M.O.D.O.K. and Arcade reveal that each family member has two robotic replicas and that they must fight to the death, unsure of who is real or fake. Jodie goes toe-to-toe with Young M.O.D.O.K. The family leaves feeling united for the first time in a while.

Catherine, Sophia, Zoe and the other survivors, finally reunited, prepare for the ultimate attack. But it is Bill who is the only one to hold the destiny of humanity in his hands, provided he is helped by Isla.

As people across the globe are experiencing hallucinations, MI5 agent Zoe contacts Bill for answers; Catherine Durand detects unusual black hole activity.

As Adina starts the next stage of her plan, astronauts Juliet and Richard see warning signs in space; uncovering Adina's sinister mission.

While working at their non-profit clinic three hours outside of Atlanta, Nic and Mina treat a patient with a failing heart VAD, forcing them to find a new battery in time to save her life. Conrad gets a call from a previous patent in crisis after being sued by Red Rock for medical expenses he can't afford. Meanwhile, Devon's VIP patient, Nadine, returns to the ER and Cain tries to get close to Bell's business partner from the supplement company.

Upon meeting with a high-profile soccer player suffering from mysterious symptoms, Conrad ends up back at Chastain and faces an angry Logan Kim. When Bell and the Raptor come up empty-handed in regard to a diagnosis, the doctors take note on how talented Conrad truly is. Nic springs into action when she notices Kyle falling into a deep depression and fears he could be suicidal. Meanwhile, Devon butts heads with Irving over patient space and Mina realizes she has become attached to baby Michelle.

Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery. Back in Seattle, Link and Jo take their kids to a fairytale theater performance that goes wrong. Bailey and Dr. Lin attend a recruitment fair in hopes of attracting more doctors to Grey Sloan but find themselves ill-prepared.

The doctors celebrate the holidays. Hamilton and Meredith prepare for a milestone on their project, while Link wants to spend the holiday with Amelia and Scout as a family. Schmitt is faced with a difficult decision during surgery.

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own. Meredith works to save Dr. Hamilton's life; Levi is impacted from his latest loss.

Schmitt must face the Morbidity and Mortality Conference. Meredith convinces Nick to scrub in on a surgery in Seattle. Jo faces her feelings.

In the aftermath of the windstorm, Andy and Sullivan's fates remain unknown while trapped in the overturned aid car. Meanwhile, back at the station, the team confronts Jack about his well-being; and when it's safe enough to venture out, they search for their fellow firefighters in a race against time.

When Andy, Maya and Dean respond to a call, they find an injured woman with amnesia; but soon into the treatment process, they realize there is much more to her story. Meanwhile, Captain Sullivan takes Ben and Jack on a house call that quickly becomes a close call for the patient they're treating, while Ryan may not have seen the last of his father, Greg.

Desire proves to be a dangerous emotion on "Desperate Housewives." Lynette and Tom uncover the unsettling truth about son Porter; Gabrielle suspects Carlos' best client has ulterior motives; Bree's moment of weakness could bring her great embarrassment and shame; and Katherine's not so little secret is unveiled. Meanwhile, Susan learns of Jackson's true passion, and Mrs. McCluskey's sister unearths a disturbing fact about Dave.

It will be a night to remember. Susan's daughter comes to visit with her surprising new boyfriend; Gaby uncovers the unsettling truth about Mrs. Hildebrand's past; Katherine has a confession to make to Susan; a reporter looks to expose Bree's imperfections; and Lynette learns Porter and Anne Schilling plan to leave Fairview and disappear. Meanwhile, everyone has gathered at a club to see the guys play in the annual "Battle of the Bands" when a fire erupts, threatening the lives of those in attendance. Some will fall as a hero will rise.

Meredith, Amelia and the team prepare for Dr. Hamilton's long-awaited groundbreaking surgery while Bailey receives an unexpected offer. Owen's impatience makes him a difficult physical therapy patient, forcing Link to intervene.

Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

The pressure of the Kennedy name weighs on John. Carolyn impresses at Calvin Klein. An unlikely connection forms at a charity event.

The road to recovery begins in the aftermath of the deadly fire that shook the citizens of Fairview. For Gaby and Carlos, injuries sustained in the fire lead to a fortunate discovery. But for most, the consequences are less forgiving. Lynette and Tom vow to protect son Porter at any cost; Susan must learn to let go of the man she loves; and Orson's attempt at a good night's sleep puts Bree in a most precarious, though amusing, position on the day of her big cooking demonstration.

Darkness lifts and brings resolution for some, while others suffer in the depths of despair. Lynette does what any mother would do to protect her son; Carlos realizes the sacrifices Gaby has made for their family; Bree longs to prove to Andrew she has accepted him for who he is; Katherine finds happiness; Susan and Mike recognize the fate of their relationship; and Dave begins to lose his grip.

An inmate violently escapes from a prison transport van. Then a witness in the escaped prisoner's murder trial is found dead. The accused murderer shows up and pleads with Megan that he is innocent and being framed.

Megan probes more deeply into her father's suicide so much that she finally gets some closure.

When a social media stunt turns deadly, Morgan and Karadec head to an influencer content house to track down answers. Meanwhile, the LAPD team adjusts to Captain Nick Wagner’s new role, and Ava seeks out more information on Roman’s disappearance.

A plane crashes in Philadelphia due to a gunman opening fire while aloft. The crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing.

An inmate violently escapes from a prison transport van. Then a witness in the escaped prisoner's murder trial is found dead. The accused murderer shows up and pleads with Megan that he is innocent and being framed.

Jack and Maya are called to treat people stuck in a subway train and discover a potential threat to the passengers and themselves. Meanwhile, Travis, Ben and Dean get pressured into inviting Sullivan to help repaint walls in Travis' house and come to a surprising conclusion about Sullivan.

It's Thanksgiving and while Meredith faces travel complications, due to the weather, Nick steps in to help – in more ways than one. Richard and Bailey seek out emergency surgeries; Amelia and Link reconnect.

The doctors celebrate the holidays. Hamilton and Meredith prepare for a milestone on their project, while Link wants to spend the holiday with Amelia and Scout as a family. Schmitt is faced with a difficult decision during surgery.

Richard ponders his surgical abilities. Jo is charmed by her patient's brother; Megan makes sure Teddy and Owen talk out their differences. A pet python causes an uproar.

Tensions at Grey Sloan Memorial rise as the effects of the physician shortage begin to show. Meredith struggles to step away from work as she spends a sick day at home with Zola. The hospital receives an unexpected visitor.

Cain feels disrespected by Logan Kim when he is left out of a major decision regarding Conrad. Meanwhile, the doctors work together to try to save the lives of two big Red Rock donors who were involved in a jet skiing accident. Then, Irving and Devon realize that three of their patients, all with different symptoms, could actually be triggered by the same thing. Also, Bell's supplement company proves to be more lucrative than anyone anticipated, but an unexpected snag could put it in jeopardy.