Following a deadly blaze inside a coffee beanery, the members of Station 19 find themselves on high alert as one of their team lands at Grey Sloan, leaving the future uncertain in the face of a life-threatening situation.

After the devastating alien attack, disparate pockets of survivors emerge into a shattered world. They quickly realise they must put their differences aside if they are to stand any chance of survival.

As the dust settles on their brave new world, the survivors are forced to face some cold truths. Catherine is stunned to discover the part she played in bringing about the alien attack. Helen becomes fixated on revenge. And Emily momentarily regains her sight. But is the miracle cause for celebration, or concern?

Threatened with expulsion, Yumyulack and Jesse continue to attend their empty high school after the school year ends. Unaware of the summer break, they believe they are being tested, and attempt to teach each other. They realize their mistake and wreak havoc on the school, and are bribed with straight As after discovering Principal Cooke and Mrs. Frankie having sex in the cafeteria. Korvo and Terry enroll in a junior college, but Terry shoots Korvo with a raygun that makes him dumber. Korvo joins Terry's hard-partying college experience, but accidentally causes the "ice lava" that powers their spaceship to flood the city, freezing everyone in its path.

Inside the Wall, Tim – imprisoned and tortured on the Duke's orders – is convinced by his cellmate Jean-Pierre to write letters calling for revolution. They are rescued by Cherie and her fellow rebels, and prepare to overthrow the Duke. Tim and Cherie spend a passionate night together, and copies of Tim's letters spread throughout the Wall, drawing people to their cause; Cherie urges Tim to lead them. As the Duke addresses a congregation, his sheriff spots Tim in the crowd and attacks, killing Jean-Pierre. Tim unites the oppressed inhabitants of the Wall in an open rebellion. The Duke floods the lower levels, drowning countless people; a farmer named Steven is unable to save his beloved mouse, Molly.

With Adina's plan for world destruction reaching completion, and our heroes in the alternate world under attack, both sides must make great sacrifices if they are to save humanity.

A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.

When Station 19 gets called to a structure fire at a coffee processing plant, the team risks their lives to save Station 42’s captain.

Friendliness is disguised as a hidden agenda. When Susan tries to impress Jessie (Swoosie Kurtz), a teacher at work, Jessie comes away with the wrong impression; with the wrong intent, Gaby convinces Carlos to hire Lynette; as Orson's shameful habit grows, Bree will protect herself from embarrassment at all costs; and a suspicious Edie slyly digs further into Dave's past.

Life is full of nasty shocks. Bree considers selling her business to save her marriage, Lynette is threatened by her new boss, boundaries are crossed for Gaby and Carlos, Katherine is caught in the most unexpected of circumstances and Edie's worst fears come true.

A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.

Due to a blood shortage, Grey Sloan Memorial sets up a voluntary donation center. Nick asks Meredith for help with his patient. Winston is hung up on his relationship with his brother.

The blood shortage continues. Meredith makes a risky decision regarding a patient. Owen's actions to help his fellow veterans come to light.

Friendliness is disguised as a hidden agenda. When Susan tries to impress Jessie (Swoosie Kurtz), a teacher at work, Jessie comes away with the wrong impression; with the wrong intent, Gaby convinces Carlos to hire Lynette; as Orson's shameful habit grows, Bree will protect herself from embarrassment at all costs; and a suspicious Edie slyly digs further into Dave's past.

Life is full of nasty shocks. Bree considers selling her business to save her marriage, Lynette is threatened by her new boss, boundaries are crossed for Gaby and Carlos, Katherine is caught in the most unexpected of circumstances and Edie's worst fears come true.

John juggles his mother’s waning health, his strained relationship with Daryl and his newfound feelings for Carolyn.

Conrad finds himself caught between his duties as a doctor and his loyalty to Kit, when he discovers that her son-in-law may be suffering from a serious disease. While moonlighting at a long-term care facility, Devon and Nic make a shocking discovery about a former patient who fell victim to Cain's manipulative practices. Meanwhile, after jumping into a new opportunity as a TV doctor, Bell is left without any surgeries and The Raptor brings him in to help on an important case.

Meredith, still functioning as the interim chief, sees Nick for the first time since she rejected his offer to move to Minnesota; Bailey tells Richard she is not ready to return to work; Levi works up the courage to break disappointing news to Jo.

The attending surgeons and interns work together to solve a medical mystery when a college kid comes in with what first looks like food poisoning but has escalating and dire complications; Jo spends her day off with Bailey.

Nicollette Sheridan takes her final stroll down Wisteria Lane in unforgettable fashion. As the women look back on Edie’s life, Susan recalls their first meeting, Lynette reflects on a memorable night out, Bree is reminded of the thoughtfulness she bestowed upon Orson, and Gaby remembers fondly a night of friendly competition.

Covering up the truth leads to unexpected consequences. Carlos finds Lynette in a precarious position, which she chooses to hide from Tom; Gaby hastily covers for Tom’s coy behavior; Orson tries to hide the truth about his wounds from Bree; Katherine confesses to Mike, which leads to a surprising realization; and Susan confides her dark secret in Dave.

Following a deadly blaze inside a coffee beanery, the members of Station 19 find themselves on high alert as one of their team lands at Grey Sloan, leaving the future uncertain in the face of a life-threatening situation.

When Rosewood and Villa suspect a brilliant doctor has killed two of his patients, they must find a way to make their case with limited evidence. Meanwhile, Villa spars with Captain Hornstock when he discourages her from pursuing an uncertain case. Also, Rosewood receives an anonymous letter revealing something that could change his life forever.

Rosewood and Villa make it their mission to seek justice for a murder victim who is an ex-con with ties to a Little Haiti gang. Meanwhile, Villa struggles with dreams she’s been having, and Rosewood deals with an unexpected turn in his relationship with Kat.

John juggles his mother’s waning health, his strained relationship with Daryl and his newfound feelings for Carolyn.

While Melinda is at the University’s botany lab she deals with some telekinetic events while dealing with a plant from Peru that is bleeding. Melinda finds that she must help a Doctor save herself.

Rosewood and Villa make it their mission to seek justice for a murder victim who is an ex-con with ties to a Little Haiti gang. Meanwhile, Villa struggles with dreams she’s been having, and Rosewood deals with an unexpected turn in his relationship with Kat.

John juggles his mother’s waning health, his strained relationship with Daryl and his newfound feelings for Carolyn.

Following a deadly blaze inside a coffee beanery, the members of Station 19 find themselves on high alert as one of their team lands at Grey Sloan, leaving the future uncertain in the face of a life-threatening situation.

Nicollette Sheridan takes her final stroll down Wisteria Lane in unforgettable fashion. As the women look back on Edie’s life, Susan recalls their first meeting, Lynette reflects on a memorable night out, Bree is reminded of the thoughtfulness she bestowed upon Orson, and Gaby remembers fondly a night of friendly competition.

Covering up the truth leads to unexpected consequences. Carlos finds Lynette in a precarious position, which she chooses to hide from Tom; Gaby hastily covers for Tom’s coy behavior; Orson tries to hide the truth about his wounds from Bree; Katherine confesses to Mike, which leads to a surprising realization; and Susan confides her dark secret in Dave.

When an unexpected piece of evidence surfaces in the 305, Rosewood and Villa attempt to solve a serious crime involving a very well-off Miami man. Meanwhile, Rosewood struggles to balance a new romantic interest with the demands of his mother, and Villa runs into trouble on the job.

Richard ponders his surgical abilities. Jo is charmed by her patient's brother; Megan makes sure Teddy and Owen talk out their differences. A pet python causes an uproar.

Tensions at Grey Sloan Memorial rise as the effects of the physician shortage begin to show. Meredith struggles to step away from work as she spends a sick day at home with Zola. The hospital receives an unexpected visitor.