The crew at Station 23 faces a difficult goodbye. Meanwhile, Andy meets a charming firefighter, and Emmett invites Travis to have dinner with his parents.

With Adina's plan in motion, the world's last hope is for Bill to make one more journey, risking his own life in search of Catherine's help.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

M.O.D.O.K. suddenly starts acting like a model employee, dutifully delivering mail and making tablets. Austin has a change of heart and tries to inform M.O.D.O.K. who really is running GRUMBL. Thrown by M.O.D.O.K.’s new behavior, Gary thinks it's Austin's fault, and Monica suspects M.O.D.O.K. is planning something against her. Eventually, M.O.D.O.K. reveals that he is selling his shares in AIM to Tony Stark and starts a new business with Monica. Austin misses the chance to tell M.O.D.O.K. the truth about GRUMBL.

M.O.D.O.K. suddenly starts acting like a model employee, dutifully delivering mail and making tablets. Austin has a change of heart and tries to inform M.O.D.O.K. who really is running GRUMBL. Thrown by M.O.D.O.K.’s new behavior, Gary thinks it's Austin's fault, and Monica suspects M.O.D.O.K. is planning something against her. Eventually, M.O.D.O.K. reveals that he is selling his shares in AIM to Tony Stark and starts a new business with Monica. Austin misses the chance to tell M.O.D.O.K. the truth about GRUMBL.

Lou's bar mitzvah doesn't attract many guests, so M.O.D.O.K. is forced to invite the villains and creatures he’s met along the season. Young M.O.D.O.K. attacks and puts the family in a precarious situation before taking M.O.D.O.K. into the time stream. Young M.O.D.O.K. reveals that if M.O.D.O.K. truly wants to take over the world, his family has to die. M.O.D.O.K. is forced to make the toughest decision of his life.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

A high-risk lung transplant pushes the surgical team to their limits; Bailey juggles a trauma patient whose treatment hangs in the balance.

The interns juggle a bizarre trauma; a complex breast reconstruction forces Meredith into a tense partnership.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

When a medical device fails on a former Chastain employee, an investigation is opened up, which pits Dr. AJ Austin against Quovadis. As Mina and Bell work to get to the bottom of what went wrong, Devon distracts himself with another patient who's experiencing mysterious stomach pains. Meanwhile, Nic forms a bond with her new partner at the clinic and Conrad's relationship with the Barnett family continues to grow.

A high-risk lung transplant pushes the surgical team to their limits; Bailey juggles a trauma patient whose treatment hangs in the balance.

The interns juggle a bizarre trauma; a complex breast reconstruction forces Meredith into a tense partnership.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.

When a nasty flu season turns out to be masking a terribly infectious disease, Chastain must race to quarantine and diagnose infected patients. While Conrad, Nic and Alec work tirelessly on Meg, who was Nic's favorite guard from her stint in prison, Devon and the others treat Sam, a love-sick patient with flu-like symptoms. Mina finds herself testing Quovadis medical devices in an effort to defend Dr. AJ Austin, who, feeling responsible for the death of a patient, is serving penance by staying away from the OR. Meanwhile, Conrad is prepared to take the next step with Nic, but finds that she may not be as ready.

Jo navigates a challenging case with a pregnant mother; Blue and Jules care for a diabetic patient; Simone treats a patient with a surprising revelation.

Grey Sloan takes in patients following a catastrophic bus accident; Teddy and Owen have an awkward encounter; Richard tests Bailey's patience.

It is raining on Wisteria Lane, six months after Mike was run over. He is now in a coma, with Susan by his side. Bree gets engaged to Orson. Gabrielle and Carlos are getting divorced, but they are briefly reunited when their 8½ months pregnant surrogate Xiao-Mei runs away. While adjusting to having another child around the house, Lynette realizes that the girl's mother, Nora, is more than she can handle.

It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.

The crew at Station 23 faces a difficult goodbye. Meanwhile, Andy meets a charming firefighter, and Emmett invites Travis to have dinner with his parents.

A murdered young woman's body turns up in place of a medical school cadaver during class, leaving Megan to rely on the aid of the star student to help solve the case.

When a pharmaceutical rep is murdered, Megan and the team must find the original crime scene if they hope to find out the cause of death and why the body was drained of blood. A big hurdle to overcome is the number of suspects with access to lots of unknown drugs.

The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.

Oz faces a deeply personal struggle when he discovers his late father's headstone was never ordered; the team investigates the murder of a tech founder obsessed with life extension.

A murdered young woman's body turns up in place of a medical school cadaver during class, leaving Megan to rely on the aid of the star student to help solve the case.

The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.

The crew at Station 23 faces a difficult goodbye. Meanwhile, Andy meets a charming firefighter, and Emmett invites Travis to have dinner with his parents.

It is raining on Wisteria Lane, six months after Mike was run over. He is now in a coma, with Susan by his side. Bree gets engaged to Orson. Gabrielle and Carlos are getting divorced, but they are briefly reunited when their 8½ months pregnant surrogate Xiao-Mei runs away. While adjusting to having another child around the house, Lynette realizes that the girl's mother, Nora, is more than she can handle.

Mike has woken up from his coma, and has no recollection of the past two years, and Edie is there to fill in the blanks. Susan is still in the country with Ian, when she receives the news. Bree finds her family is anything but perfect. Lynette is determined not to let Parker quit baseball because he made a commitment, even though he's terrible at it. Carlos moves back into the Solis house, much to Gabrielle's displeasure.

Winston and Ben fight to save Jo's life; Teddy supports Link; Owen and Jules battle to save a young man; Lucas forms an unexpected bond with a patient.

Bailey and Owen join forces to save a tumor patient; Richard faces an internal battle; Jules struggles with her feelings for Winston.

Conrad, Kit, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.