As if being co-captains weren’t hard enough, Andy and Jack find themselves in disagreement over spending decisions at the station. Meanwhile, the firefighters respond to a structure fire at a brand-new bed-and-breakfast; and Ryan calls Maya when he finds her brother in some trouble.

The epic series finale sees the survivors attempt to turn the tables on their aggressors once and for all. Mokrani and Catherine prepare for the fight of their lives. Emily seeks answers, at any cost. And Sacha’s visions continue, giving a confounding glimpse of the future…

London, four months after the attack. The survivors organize the Resistance. Bill continues his research on aliens and understands that their DNA is human but that their organs are degenerating. In France, a severely wounded dissident alien reaches the Observatory

M.O.D.O.K brings Melissa and Lou along to a remote GRUMBL leadership conference. After learning that he's not the guest of honor, M.O.D.O.K. enlists Melissa's help in manipulating the executives into respecting him. His schemes accidentally lead to him opening up a portal that brings the dangerously hedonistic alien species, the Ciegrimites, to the conference. While the aliens are initially the life of the party, executives begin to drop dead from partying too hard, leading M.O.D.O.K. and Melissa to wipe out the Ciegrimites and save the conference.

M.O.D.O.K brings Melissa and Lou along to a remote GRUMBL leadership conference. After learning that he's not the guest of honor, M.O.D.O.K. enlists Melissa's help in manipulating the executives into respecting him. His schemes accidentally lead to him opening up a portal that brings the dangerously hedonistic alien species, the Ciegrimites, to the conference. While the aliens are initially the life of the party, executives begin to drop dead from partying too hard, leading M.O.D.O.K. and Melissa to wipe out the Ciegrimites and save the conference.

After getting kicked out of the A-List villains' Soho Lair, M.O.D.O.K. decides to slum it at The Bar With No Name. There, he forms a crew of street-level baddies, intent on using them for a heist that will get him back into the Soho Lair. However, after a wild night of bonding and backstory sharing, they form a real camaraderie. Meanwhile, Jodie goes looking for M.O.D.O.K. at AIM and bonds with Monica while Lou meets Monica's daughter, Carmilla. College-aged M.O.D.O.K. has returned from the time stream and kidnaps the Super Adaptoid.

London, four months after the attack. The survivors organize the Resistance. Bill continues his research on aliens and understands that their DNA is human but that their organs are degenerating. In France, a severely wounded dissident alien reaches the Observatory

When one of Grey Sloan's own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.

Meredith considers her loyalties, as Alex deals with the repercussions of his actions. Newlyweds Amelia and Owen host a dinner party with unlikely guests, and Jackson proposes an arrangement to help April through her recovery.

All of Wisteria Lane gathers at Pizzeria Scavo for the grand opening event, while one resident meets an untimely fate and another accepts a marriage proposal.

Edie gets an unexpected visit from her son. An unexpected pregnancy causes complications. Victor Lang, a man in his 40s running for mayor of Fairview, introduces himself for Gabrielle. The deceased Rex Van De Kamp narrates.

When Atlanta is struck by a severe snowstorm, Mina must perform a big surgery – without the help of The Raptor – to save the life of a young father, while Kit and Bell get stuck babysitting the man's children. Nic and Conrad experience a disagreement with a patient's treatment, causing further strain in their relationship. Meanwhile, Devon teaches an important lesson about life and death to a first-year med student.

When one of Grey Sloan's own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.

Meredith considers her loyalties, as Alex deals with the repercussions of his actions. Newlyweds Amelia and Owen host a dinner party with unlikely guests, and Jackson proposes an arrangement to help April through her recovery.

All of Wisteria Lane gathers at Pizzeria Scavo for the grand opening event, while one resident meets an untimely fate and another accepts a marriage proposal.

Edie gets an unexpected visit from her son. An unexpected pregnancy causes complications. Victor Lang, a man in his 40s running for mayor of Fairview, introduces himself for Gabrielle. The deceased Rex Van De Kamp narrates.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong (guest star Conrad Ricamora). Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

Devon grows concerned when a mother's complaints go unaddressed after her delivery, and pushes Bell to take drastic measures. Conrad is faced with breaking the news to Nic regarding Jessie's worsening condition. Meanwhile, The Raptor, Mina and Kit spring into action when a mother and son enter the ER with devastating injuries.

A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.

Alex tries to do the right thing but still can't catch a break. Jackson and April adjust to their "new normal" with the baby. While Meredith and Nathan establish what's going on between them, Amelia questions the state of her relationship with Owen.

Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.

Susan considers moving from Wisteria Lane to London. Later, an accident causes Ian, Susan, and their car to find themselves stranded in a lake. Tom feels threatened by the interest a new Scavo's Pizzeria employee Rick shows in Lynette. While debating his opponent in the mayoral election, Victor Lang witnesses something disturbing.

As if being co-captains weren’t hard enough, Andy and Jack find themselves in disagreement over spending decisions at the station. Meanwhile, the firefighters respond to a structure fire at a brand-new bed-and-breakfast; and Ryan calls Maya when he finds her brother in some trouble.

A case of mistaken identity mars a case when two young girls are in a tragic car accident. The wrong girl may have been pronounced dead and the actual cause of death is in question.

When a son discovers his murdered parents, the team soon realizes that this perfect family wasn't really perfect. Megan has a new love interest and Curtis is grappling with his new position.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong (guest star Conrad Ricamora). Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

Rosewood and Villa head back to Villa’s roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant.

A case of mistaken identity mars a case when two young girls are in a tragic car accident. The wrong girl may have been pronounced dead and the actual cause of death is in question.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong (guest star Conrad Ricamora). Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

As if being co-captains weren’t hard enough, Andy and Jack find themselves in disagreement over spending decisions at the station. Meanwhile, the firefighters respond to a structure fire at a brand-new bed-and-breakfast; and Ryan calls Maya when he finds her brother in some trouble.

Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.

Gabrielle and Victor will make an unexpected twist in their relationship and will also face a crisis as a video of them sharing a passionate moment in an elevator was caught on tape and is now being used to blackmail them. Edie gets into a fight with one of the ladies that will ruin their "friendship" while another lady on Wisteria Lane ends up in the hospital.

Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.

Meredith and Bailey are at odds when both of their patients need a liver transplant, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for the day, and Amelia struggles with telling Owen some important news.