Ripley interviews each member of the Station 19 crew to determine whether Andy or Jack should be given the role of captain. Meanwhile, a mom’s day out on a party bus takes a turn for the worst; and Captain Pruitt continues his treatment.

Catherine, Sophia and Nathan make their way to London, accompanied by Victor, a survivor encountered by chance. Along the way, the dangers multiply. Sacha's feelings towards Emily intensify and the young man's behavior becomes more and more disturbing. Feeling threatened, Bill is forced to flee.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

Trying to emulate human males, Korvo and Terry create their own man cave and “"P.A.T.R.I.C.I.A.", a robot based on female sitcom characters, programmed to hate the man cave. Korvo and Terry realize the robot fulfills their respective desires for a nagging wife and a nurturing mother, and invite her inside the man cave. Torn between her conflicting directives, P.A.T.R.I.C.I.A. transforms into a heavily-armed killing machine and destroys every man cave in the neighborhood. Ms. Perez, Jesse's gender studies teacher, assigns the class to challenge a glass ceiling. Jesse confronts several school extracurriculars, but is disappointed to learn they already welcome women.

Trying to emulate human males, Korvo and Terry create their own man cave and “"P.A.T.R.I.C.I.A.", a robot based on female sitcom characters, programmed to hate the man cave. Korvo and Terry realize the robot fulfills their respective desires for a nagging wife and a nurturing mother, and invite her inside the man cave. Torn between her conflicting directives, P.A.T.R.I.C.I.A. transforms into a heavily-armed killing machine and destroys every man cave in the neighborhood. Ms. Perez, Jesse's gender studies teacher, assigns the class to challenge a glass ceiling. Jesse confronts several school extracurriculars, but is disappointed to learn they already welcome women.

Threatened with expulsion, Yumyulack and Jesse continue to attend their empty high school after the school year ends. Unaware of the summer break, they believe they are being tested, and attempt to teach each other. They realize their mistake and wreak havoc on the school, and are bribed with straight As after discovering Principal Cooke and Mrs. Frankie having sex in the cafeteria. Korvo and Terry enroll in a junior college, but Terry shoots Korvo with a raygun that makes him dumber. Korvo joins Terry's hard-partying college experience, but accidentally causes the "ice lava" that powers their spaceship to flood the city, freezing everyone in its path.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza's presence at Grey Sloan.

Bailey, Arizona and Jo go to a maximum security women's prison to treat a violent, 16-year-old pregnant girl and her unborn baby.

As Gabrielle prepares for her fairy tale wedding, Bree returns to Fairview with a surprise. Meanwhile, Lynette's mother Stella pays her a visit after finding out Lynette has cancer. Finally, Susan and Mike tie the knot in an unexpected location.

The neighborhood is shocked when news about Edie's suicide attempt spreads though Fairview. Lynette battles with the effects of chemotherapy. After a decade of absence, Katherine Mayfair moves back to Wisteria Lane with her new husband and daughter in her late teens.

In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad’s help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah’s surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.

Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza's presence at Grey Sloan.

Bailey, Arizona and Jo go to a maximum security women's prison to treat a violent, 16-year-old pregnant girl and her unborn baby.

As Gabrielle prepares for her fairy tale wedding, Bree returns to Fairview with a surprise. Meanwhile, Lynette's mother Stella pays her a visit after finding out Lynette has cancer. Finally, Susan and Mike tie the knot in an unexpected location.

The neighborhood is shocked when news about Edie's suicide attempt spreads though Fairview. Lynette battles with the effects of chemotherapy. After a decade of absence, Katherine Mayfair moves back to Wisteria Lane with her new husband and daughter in her late teens.

At work, a toxic marriage leaves lasting scars. After hours, Allura tends to her own.

The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital. Conrad finds himself in a dangerous situation when the construction for a new neurosurgery center causes a gas explosion at Chastain. Meanwhile, new hotshot neurosurgeon Barrett Cain, is put to the test with a complicated surgery and Mina acts as a support for Nic, who is struggling with a devastating loss.

Richard and the attendings set out to make Eliza's first day at Grey Sloan a bumpy one. Meanwhile, Meredith tries to track down Alex.

Maggie gets a surprise visit from her mother at the hospital. Bailey has to make a difficult decision when one of the attendings refuses to work with Eliza, and Stephanie gets caught up in Owen and Amelia's personal drama.

Lynette kicks Tom out of her chemotherapy sessions. Susan is mistaken for a stripper. Bree attempts to steal a prize-winning recipe from Katherine.

Bree informs the housewives of what she overheard in the Mayfair house. Stella makes some special brownies to help Lynette through chemotherapy. Susan throws a charades party for the whole neighborhood.

Ripley interviews each member of the Station 19 crew to determine whether Andy or Jack should be given the role of captain. Meanwhile, a mom’s day out on a party bus takes a turn for the worst; and Captain Pruitt continues his treatment.

As Megan returns to work months after Peter's death, she is thrown together on a new case with a detective from her past. A serial killer is seeking out young war veterans but the case hits close to home for Megan when the killer takes Lacey hostage.

A new case has similarities to a past case and a serial killer Megan helped send to prison.

At work, a toxic marriage leaves lasting scars. After hours, Allura tends to her own.

When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain’s doctors to put aside their personal issues to try and save his life. Conrad and Nic team up to help one of the crash victims, whose secretive past makes it difficult to identify a diagnosis. Meanwhile, Bell brings his TV crew to the hospital in hopes of garnering positive attention for Chastain, and Mina opens up to Nic, only to find out that Nic is holding on to a secret of her own.

As Megan returns to work months after Peter's death, she is thrown together on a new case with a detective from her past. A serial killer is seeking out young war veterans but the case hits close to home for Megan when the killer takes Lacey hostage.

At work, a toxic marriage leaves lasting scars. After hours, Allura tends to her own.

Ripley interviews each member of the Station 19 crew to determine whether Andy or Jack should be given the role of captain. Meanwhile, a mom’s day out on a party bus takes a turn for the worst; and Captain Pruitt continues his treatment.

Lynette kicks Tom out of her chemotherapy sessions. Susan is mistaken for a stripper. Bree attempts to steal a prize-winning recipe from Katherine.

Bob & Lee's contemporary water sculpture in their front yard prompts the Wisteria Lane neighborhood association into action. Edie finds out about the affair that Carlos is having with Gaby. Also, John Rowland wants to rekindle his romance with Gaby.

The residents are excited for Eliza's next phase of teaching, but they spend the day caught between the warring attendings. Meanwhile, April has a challenging first day in her new role at the hospital.

Alex returns to the hospital and discovers a lot has changed since he left. Meanwhile, Jo has to make a difficult decision on a case, and Arizona tries to distance herself from Eliza

Cain tries to recruit Bell and Kit to join him on a dangerous surgery, with the intent of garnering publicity for the hospital. Meanwhile, the Raptor finds himself with an emotional attachment to a patient whose life is put in his hands and Mina's friend, Adaku (guest star Erinn Westbrook), arrives at the hospital with shocking news. Also, Devon rotates out of the ER and Nic plans a surprise for Conrad